Breaking
News
Proposed Federal Funding for 2012
Legislators are considering supporting this
proposed funding package for 2012.
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$588.94 billion for the Department of Health and
Human Services, which is an increase of $15.1 billion over FY 2011 and $3.66 billion less than the
president’s request.
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$6.12 billion for the Centers for Disease Control
and Prevention (CDC), a decrease of $157 million from FY 2011 and $269 million less than the
president’s request.
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$33.48 billion for the Substance Abuse and Mental
Health Services Administration (SAMHSA), a decrease of $27 million from FY 2011 and $72.69
million less than the president’s request.
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$30.7 billion for the National Institutes of
Health, an increase of $300 million over FY 2011 and $58 million less than the president’s request.
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$71.28 billion for the ‘department of education,
a decrease of $kk151.1 million from FY 2011 and $9.25 billion below the president’s request.
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$53.12billion for the Veterans Health
Administration, an increase of $1.98 billion over FY 2011 and
$72.23 million more than the president’s request.
-
$6.48 billion for the Health Resources and
Services Administration, a decrease of $41 million from FY 2011 and $850 million less than the
president’s request.
It is anticipated that this will be approved and
signed by the president shortly.
Hepatitis Foundation International Call to Action for World
Hepatitis Day: Get Tested, Get Immunized, and Help Prevent New
Infections.
Hepatitis Foundation
International, dedicated to liver health and the prevention of
liver related diseases, urges people to get tested and immunized
to help prevent new
viral hepatitis infections.
“We have the power to prevent new
hepatitis infections, whether hepatitis A, B or C, through
immunizations, avoiding risky behaviors such as
sharing needles, toothbrushes and razors, and encouraging those
as risk for infection to get tested,” said Thelma King Thiel,
CEO and Chairman, HFI.
The goal of World Hepatitis Day
was to increase awareness of viral hepatitis and the diseases
that it causes. Viral hepatitis is a significant burden across
the globe accounting for:
-
130 million people
chronically infected with
hepatitis C;
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An estimated 2 billion
people worldwide infected with hepatitis B;
-
1.4 million cases of
hepatitis A annually.
In the United States, chronic
hepatitis C and hepatitis B infections continue to persist while
hepatitis A infections have been dramatically decreased due to
increased awareness and hygiene. Because viral hepatitis can
persist for decades without symptoms, 65%-75% of infected
Americans remain unaware of their infection status and are not
receiving care and treatment. In May of this year the Department
of Health and Human Services issued the National Viral Hepatitis
Action Plan to prevent disease and help those who are diagnosed.
HFI knows of the urgency to make
this action plan happen, especially the need to identify the
large at-risk population of Baby Boomers, who are likely unaware
of their infection. HFI urges people to take the following steps
to prevent hepatitis and preserve their liver:
-
Get tested. For information
about testing contact your local public health
department or your doctor.
-
Get vaccinated. Vaccinations
for hepatitis A and B are available.
-
Get educated and protect your
liver. The liver is vital for overall health. Avoid
drugs, alcohol and limit the amount of fatty, unhealthy
foods, all of which damage the liver.
About Hepatitis Foundation International
The mission of the Hepatitis Foundation International is to
promote liver wellness, healthy lifestyles, and reduce the
incidence of preventable diseases that affect the liver
including obesity, diabetes, fatty liver, hepatitis, HIV, and
substance abuse. For information visit
http://www.hepatitisfoundation.org.
Carrie Sessine
Graceful PR
(202) 618-0567
New Liver-Like Cells Enhance HCV Research
Researchers at MIT, Rockefeller University and the Medical College of Wisconsin have found a way to create liver-like cells from induced pluripotent stem cells (iPSCs), which are made from body tissues rather than embryos. These liver-like cells can then be infected with hepatitis C. Studying liver cells from various people could reveal genetic factors to enhance efforts to understand why some people are resistant to hepatitis C, while others are highly susceptible to this infectious disease.
Along with benefiting hepatitis C research, the new technique may eventually have a role in personalized medicine, the researchers said in a MIT news release. By testing the effectiveness of different drugs on tissues derived from a patient, doctors may be able to customize therapy for patients.
Drug Induced Liver Injury
Drug-induced liver injury is the most common cause of acute liver failure in the US with overdoses of acetaminophen identified as the most frequent cause of liver injury. . Liver toxicity limits the development of many therapeutic compounds and presents major challenges to both clinical medicine and to the pharmaceutical industry causing abandoning drugs early in development or withdrawal from the market. Currently, no pharmaceutical strategies exist for preventing drug-induced liver injury and treatment options are limited to discontinuing the offending drug, supportive care, and transplantation for end-stage liver failure.
Suraj Patel, a postdoctoral researcher at Massachusetts General Hospital and Marti Yamush at Rutgers have developed a clinically viable strategy that targets a liver’s gap junctions—hollow multimolecular channels that connect neighboring cells and allow direct communication between coupled cells. They have shown that gap junctions spread immune signals from injured liver cells to surrounding undamaged cells, amplifying inflammation and injury. The current study examined inhibiting the action of liver-specific gap junctions to limit drug-induced liver injury. Much more needs to be known about any off-target effects of gap junction inhibitors and better understand the long-term ramifications of temporarily blocking liver-specific gap junction channels before applying this approach to patients, according to Dr. Patel.
Childhood Obesity-
Thousands at Risk
Doctors in the U.K say obesity levels are now so
high that children are commonly suffering signs of disease more
commonly associated with alcohol abuse, meaning many will go on
to develop cirrhosis, with some requiring liver transplants.
Government estimates say around 500,000 children
below the age of 15 are suffering from “non alcoholic liver
disease” which is caused by a build-up of fat within liver
cells.
The condition increases the risks of heart
disease, strokes and type 2 diabetes, and can lead to
cirrhosis-scarring of the liver-which is often not detected
until it is too late. Thousands of lives are already at risk.
Prof. Martin Lombard, the Department of Health’s
national clinical director for liver disease warned that the
disease was rarely detected until it had caused damage. He said
“Liver disease is a killer, which is putting the lives of
thousands of our children at risk. We do not want to see the
next generation dying young from a condition that can be
prevented.”
Prof Lombard said he was concerned that children
suffering from fatty liver disease were at particular risk if
they started experimenting with alcohol in teenage years. He
said even modest amounts of alcohol could worsen the condition.
There is no medical treatment for the disease, but the extent of
it can be reduced by weight loss and improvements in diet. Young
people who are over weight or obese need to make simple changes
to their lifestyle.
Are You Feeding Your Heart Too
Much Mayo??
What does
the heart have to do with mayonnaise, grease and cheese??? A
recent article by Web MD titled
Do Your Heart a Favor: Avoid These Appetizers
identified some good and bad choices.
To help
you make good choices, we’d like to connect the heart
with the food you eat. . . and your
liver
that processes the food (fuel) you feed it that keeps you alive
and functioning 24/7.
Loading up
your liver with fats, too much sugar and carbohydrates can not
only
clog up your arteries,
they can
damage your liver . . .your
internal chemical converter and energy source.
Did you
know that almost everything you eat has to be processed by your
liver? Clogging it up with too many fatty foods can compromise
this process. One in 6 Americans has a fatty liver
that can lead to cirrhosis.
When you
learn you have high cholesterol, what is the first
thing you are told to do?
Change
your diet!!! Did you know that your
liver
is responsible for the production and
excretion
of cholesterol? What are you eating that is helping your
cholesterol
go through
the roof?
Learn how
to take care of liver. Visit
www.PartnersinLiverWellness.org
Mental Confusion; Is it
Alzheimer’s or Cirrhosis??
Most of us
are well aware of the signs of mental confusion related to
Alzheimer’s Disease. However, cirrhosis and liver failure can
cause similar symptoms due to the liver’s inability to remove or
process toxins ingested in food, drugs and alcohol, and those
made in the body. These toxins remain in the blood and are
carried to the brain where they affect cognition.
Several
liver related diseases can lead to cirrhosis including: fatty
liver, viral hepatitis, autoimmune hepatitis, Wilson’s disease,
and alcohol abuse, and many others.
Most
people do not think of obesity as a liver problem; however,
two-thirds of Americans are overweight without a clue that
overeating and eating too many fatty foods can lead to cirrhosis
of the liver.
Almost
everything you eat, breath and absorb through your skin must be
processed through you liver.
Liver
transplants are very expensive, Changing your diet and
protecting your liver is a cost effective way to (be a long
liver) live a longer and healthier life.
HCV Infected? Protecting Your Liver
An
increasing number of chemicals in pesticides, aerosols, cleaning
agents, waxes and lacquers and other
pollutants in the environment are leading to liver damage. The
liver is the primary organ in the human body
that metabolizes foreign compounds such as drugs, alcohol,
cigarette smoke and
environmental chemicals including those on the foods we ingest.
It needs your help when it is
struggling with hepatitis B or C infections.
There is a
lack of comprehensive understanding of the cell-and organ-wide
effects of mixtures of toxic
substances and how interactions among them can lead to increased
liver damage. Much more
research is needed to prevent or mitigate life-threatening
toxicant-induced liver health issues. Until then
be sure to wash fruit and vegetables before eating them; have
proper ventilation when using sprays and/or
wear a mask; and cover your skin and wash it thoroughly if
exposed to weed killers, bug sprays,
paint
thinners, or other chemicals used in and around your house.
Words to
live by; Almost everything you eat, breathe or absorb through
your skin has to be
processed and detoxified by your
liver.
Your liver
is your silent partner that depends on you to protect it from
harm.
HFI Jump Starts Viral Hepatitis
Action Plan.
The Hepatitis
Foundation International (HFI) applauds the U.S. Department of
Health and Human Services (HHS) for its Action Plan to Prevent,
Care and Treat Viral Hepatitis, a silent and underestimated
public health problem. Implementation of the plan depends on
government support to be effective. HFI knows of the urgency to
make this action plan happen, especially the need to identify
the large at-risk population of Baby Boomers of whom many
are unaware of their infection. For many years the Foundation
has developed programs and worked to engage healthcare
providers, and community and corporate leaders to promote liver
health/wellness programs and empower individuals to assess their
own risk of infection, seek testing and take advantage of new
treatments and subsequent cures.
To promote
liver health education, missing in most prevention programs, HFI
continues to reach and engage leading organizations including
Georgia Power/Southern Company and The Coca Cola Company to
join Partners in Liver Wellness, HFI's initiative to encourage
liver health education in the workplace.
Georgia
Power/Southern Company, who was impressed with HFIs liver health
program that promotes healthy lifestyle behaviors and avoidance
of liver damaging activities, provided the liver health
information to its 9,000 employees through their Safety
Education Program. Their medical director, Dr. Rob Harshman
said, “ I am happy to hear there is growing momentum to educate
people in protecting their livers through healthy lifestyles. It
is a message we have to continually revisit.”
“We can not
afford to wait until people get sick. Understanding the
important role the liver plays is essential to enable
individuals to avoid liver related debilitating chronic
illnesses that include hepatitis, fatty liver, obesity, diabetes
and alcohol and drug misuse and abuse”, says Dr. Raymond Koff,
hepatologist and clinical professor at University of
Connecticut Health Sciences Center.
Prevention
depends on individuals making personal healthy lifestyle
choices. Education is the key.
Alarming Increase of HCV Among Young
Adults
A report
from the Massachusetts Department of Health showed an alarming
increase in the rate of Hepatitis C Infection among young adults
age 15 – 24. This was nearly double the rate between 2002 and
2009. According to state
officials, this new wave of disease is attributed to the rise in
abuse of Percocet and oxicodone leading to participation in
intravenous drugs use by
young adults, The increase is purported to be linked to sharing
infected needles to inject the drugs.
“We can
not afford to wait until young adults are infected to address
this increasing health problem,” comments Dr. Raymond
Koff, hepatologist and clinical professor at Connecticut
University Health Sciences Center. “Educating children at an
early age
about the
important role the liver plays and how drugs and alcohol can
impact their health and life itself is essential to empower
young people to make informed choices and avoid the life
altering impact of being hepatitis C infected.”
Absent in
most primary and secondary school curricula is information about
liver health and adoption of healthy lifestyle behaviors.
Extensive surveys by the Hepatitis Foundation International
(HFI) show that the majority of teachers lack the knowledge and
teaching tools to engage their students in avoiding liver
damaging behaviors. Prevention of hepatitis C and other liver
related diseases can save lives
and
healthcare dollars. HFI’s Partners in Liver Wellness educational
initiative is recognized nationally for its leadership in
promoting liver health and healthy lifestyles. For information
and participation in promoting liver health call 1-800-891-0707
Two New Drugs Provide Hope for More Cures
The U.S.
Food and Drug Administration (FDA) has approved two new drugs;
telaprevir (Incivek, Vertex) and boceprevir (Victrelis, Merck)
to be used with peginterferon plus ribavirin for the treatment
of Hepatitis C virus (HCV) infection, thereby providing new hope
for patients who are infected. Both drugs are serine protease
inhibitors and cannot be used as monotherapy.
Telaprevir
is approved for the treatment of chronic hepatitis C genotype 1
infection, in combination with peginterferon and ribavirin, in
patients aged 18 years and older with compensated liver disease,
including cirrhosis, who are treatment-naive or who have been
previously treated with interferon-based treatment. Patients who
received 750 mg of telaprevir every 8 hours with meals along
with the conventional treatment of peginterferon plus ribavirin
had a significantly higher rate of sustained virologic response
(SVR) of 79%, considerably higher than the rate observed in
patients receiving conventional therapy. The SVR response rate
for all patients across all studies and all patient groups, was
20% to 45% higher than the current standard of care. Treatment
with telaprevir is limited to 12 weeks with peginterferon plus
ribavirin, and then the peginterferon and ribavirin are
continued for an additional 12 weeks for a total of 24 weeks of
treatment in most patients. Some patients, about 40%, with
require longer therapy with peginterferon and ribavirin.
Patients who had relapsed from prior therapy achieved a SVR of
86%, while those with a partial response had a SVR of 59% and
so-called null responders had the lowest SVR of 32%. Anemia was
a common adverse event and serious skin reactions with
telaprevir occurred in less than 1% of patients.
Boceprevir,
also approved for the treatment of genotype 1 chronic hepatitis
C patients with compensated liver disease, including cirrhosis,
who are over 18 years of age, is given four weeks after
beginning the combination of peginterferon plus ribavirin in a
lead-in phase. The dose of 800 mg is given orally with food
every 7 to 9 hours. Boceprevir may given for 24 weeks together
with peginterferon plus ribavirin, following the four-week
lead-in phase, in about 45% of patients, and for 44 weeks in the
remainder, based on HCV RNA levels measured at weeks 8 and 24.
For naive patients, SVR was achieved in 63-66% of patients.
Patients who previously had relapsed or had a partial response
when treated with peginterferon and ribavirin, achieved a SVR of
70-75% and 40-52%, respectively. Null responders, defined as
individuals in whom HCV RNA levels failed to decline by at least
2 logs at week 12 of previous treatment were not included in
Phase III studies but in earlier studies, SVR rates were less
than 15%..Adverse effects of concern include: anemia,
neutropenia and thrombocytopenia but serious skin reactions were
not seen.
As with
conventional treatment, patients need to be warned that both
treatment regimens have the potential to cause depression,
suicidal ideation and, if taken during pregnancy, birth
defects. Because of drug-drug interactions, it is essential that
all medications be carefully reviewed before beginning either
therapy
Nonalcoholic Fatty Liver
Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH)
Fat accumulation in the liver in individuals who
do not drink alcohol, is called nonalcoholic fatty liver disease
(NAFLD). As a consequence of the on-going obesity epidemic in
the U.S., fatty liver is a very common disorder with an
estimated two thirds of obese adults and half of obese children
having fat accumulation in the liver. Up to 20% of those who are
obese may suffer from a more severe condition called
non-alcoholic steatohepatitis, (NASH). This occurs when fat
build up in the liver is associated with liver cell inflammation
and various degrees of liver cell death called
cirrhosis. In many of
those affected by NAFLD, obesity may be the only warning of a
fatty liver. Some people may have a slightly enlarged liver,
feel tired and have some abdominal pain. However, fatty liver
is suspected when a blood test of specific liver enzymes (serum
aminotransferease enzymes) is elevated in an individual who is
obese. Fatty liver can be confirmed by an ultrasound examination
of the liver or by liver biopsy.
Read more:
NAFLD Article
HFI Launches Partners in Liver Wellness Initiative
The Hepatitis Foundation International hosted the
launch of its Partners in Liver Wellness initiative in Atlanta, Georgia. Partners in Liver Wellness is a call to action to
address the rising tide of preventable liver diseases, including hepatitis, fatty liver disease, and drug use and abuse and alcohol-related liver disease among
America’s workforce.
By enlisting leaders from the corporate and public health
communities this
national initiative will help employers promote liver
health/wellness filling the enormous knowledge gap in liver health
education. Our goal is to save lives and reduce healthcare costs by
empowering individuals to understand the importance of the liver in
maintaining healthier, more productive lives. 
Former NFL Coach Dan Reeves,
co-chair of this initiative, reported that “Listening to a
presentation on the importance of the liver had the greatest impact
on my teams motivating them to take care of themselves and avoid the
pitfalls of participating in liver damaging behaviors. We need
to reach out to our community leaders to help our children, families
and employees
take responsibility
for their own healthcare and adopt healthier lifestyles”
HFI is conducting a series of
Partners in Liver Wellness
meetings to bring these importance awareness messages
to communities across the nation. For more information:
call Thelma King Thiel at 1-800-891-0707.
The
Influence of NAFLD and Its Associated Co-morbidities on Liver
Transplant Outcomes
Non-Alcoholic Fatty Liver Disease is a rising
epidemic in the US, fueled in part by the dual epidemics of
obesity and diabetes. As NAFLD increases in incidence and
prevalence, researchers expect it to become the leading
indication for liver transplantation in the next two decades.
The abstract of a new study from the University of North
Carolina, Chapel Hill was presented at Digestive Disease Week,
May 1-5 in New Orleans, LA. The study found that NAFLD is
significantly associated with worse transplant outcomes (death
and graft failure) within the first 30 days after a liver
transplant. The study, which observed 118 liver transplants in a
three-year period, is based on previous research published in
2009 that reached similar conclusions.
Read more:
DDW 2010
Antiviral ‘Cocktail’ Better
than Single Drug for Children with Hepatitis
An estimated 132,000 U.S. children are infected
with the Hepatitis C virus, and nearly 42,300 of them are
chronically infected. Children receiving the combination therapy
of PEG interferon injections and the antiviral drug Ribavirin
cleared the infection at a rate of two and a half times greater
than children receiving PEG interferon treatment alone according
to a study conducted by Johns Hopkins Children Center. Viral
clearance occurs when the blood is free of viral traces at the
end of the treatment, and sustained viral clearance occurs when
the blood remains clear for at least six months after stopping
treatment. Full clearance is the hallmark of effective therapy
and was where the greatest differences between the two
treatments emerged. The study showed that combination therapy
proved more effective in clearing the Hepatitis C virus in
children ages 5-17, and children receiving the combination
therapy were less likely to relapse after stopping treatment,
with only 17 percent compared to the 45 percent of children on
the single-drug approach.
Read more:
Johns Hopkins Children's Center
Spice in Curry Could Prevent Liver Damage
Curcumin, a spice regularly found
in curry and contained in the Tumeric plant could serve as a
natural way to help prevent and treat liver damage caused by
fatty liver disease. Fatty liver disease, linked to obesity and
weight gain, affects an estimated 3 to 4 percent of the US
population and if left untreated can lead to cirrhosis, liver
cancer and even death. Research has shown that obese patients
typically have higher levels of blood leptin, glucose and
insulin, all of which might contribute to liver fibrosis, the
scarring of the liver. Elevated levels of leptin activate
hepatic stellate cells, which in turn overproduce collagen
protein, a major factor of liver fibrosis. Preliminary research
released by Saint Louis University suggests that Curcumin
minimizes the effects of leptin on activating hepatic stellate
cells, which in turn helps to lessen the development of liver
damage.
Read More:
Science Daily
Childhood Obesity- Impact of Liver Transplant
Studies show that obesity has a significant
negative impact on pediatric patient survival more than 5 years
post-liver transplant. A study examined the impact of
pre-transplant Body Mass Index (BMI
-
a measure of someone’s weight in relation to their
height) on post liver transplant survival in the pediatric
population. Results indicated children who were thin or
severely thin had a significantly lower survival (84%) at one
year compared to the survival (89%) of children in the normal
and overweight groups. However by the 12th year
following liver transplant, those in the obese group had
significantly lower survival (72%) than the survival (77%) of
normal or overweight pediatric patients. The study conducted by
the University of Washington concluded that identifying pre and
post transplant pediatric patients as malnourished or obese
along with optimization of their modifiable risk factors will
help maximize patient survival by better utilizing scarce donor
organs.
Read More:
Science Daily
Liver Hormone is a Cause of Insulin Resistance
The hormone, Selenoportein (SeP), produced and
secreted by the liver was previously an unknown cause of insulin
resistance. Research shows that the livers in people with type
2 diabetes who are more insulin resistant express higher levels
of gene encoding Selenoportein P (SeP). Blood levels of SeP are
also increased in people with diabetes compared to healthy
people. This finding suggests a new target for the treatment of
insulin resistance and type 2 diabetes. This study published by
Kanazawa University Graduate School of Medical Science in Japan
further shows there may be other hormones derived from the liver
with important and varied roles in the body.
Read More:
Physorg.com
New Serum Marker for Hepatocellular Carcinomaa
New findings have shown that the combined measurement of golgi
protein 73 (GP 73) and alpha-fetoprotein (AFP) increased the
sensitivity for hepatocellular carcinoma (HCC). GP73 decreased
following surgical resection of HCC lesions and increased with
tumor recurrence. Non-liver cancers in 14 organs (colon, rectum,
stomach, esophagus, pancreas, lung, thyroid, kidney, bladder,
prostate, breast, ovary, cervix and endometrium) were analysed.
In conclusion, the authors submitted that GP73 is an accurate
serum marker for the detection of hepatocellular carcinoma (HCC)
and its recurrence after surgery. It had a higher sensitivity
and specificity than alpha-fetoprotein (AFP). Also, they
recommended clinical implementation of serum GP73 measurement as
a standard test for hepatocellular carcinoma (HCC)
Read More:
GUT Online
FDA
Considers Expanded Use of HCV Drugs
The FDA is considering the establishment of a
compassionate use program that would allow severely ill
hepatitis C (HCV) patients access to investigational,
direct-acting antiviral agents. This effort to control Hepatitis
C more effectively is in response to a petition by groups
seeking access to the drugs for individuals often excluded from
clinical trials, which are only open to a small subset of
real-world HCV patients. Many patients are rejected from
clinical trials due to co-morbidities, drug use, and mental
illnesses. Check out the rest of the article, which features
commentary from Dr. Diana Sylvestre, a speaker at HFI's Viral
Hepatitis Summits:
Read More:
MedPage Today
Many Kids with Hepatitis C are Missed
Many children
with hepatitis C go undiagnosed and untreated, which can lead to
severe liver damage later in life. National data shows that
between 0.2 percent and 0.4 percent of children in the United
States is infected with hepatitis C. Most children and adults
infected with hepatitis C do not have symptoms or they may have
fatigue or
abdominal pain. This results in the lack of proper
identification. Most young children get the infection from their
mothers while in the
womb, which
accounts for about 60 percent of the infections in young
children. Teenagers can get it through IV drug use and other
substance abuse. Unfortunately, there is a widespread lack of
awareness of the condition and adequate screening is not often
done. Moreover, children are too often not referred to
treatment. Early identification of pediatric hepatitis C
infection would likely help us cure the infection in over 50
percent of children that currently have it.
Read more:
U.S. News Health
Deadly Cancer is Preventable
Liver cancer, or hepatocellular carcinoma (HCC),
is the third leading cause of death from cancer worldwide and
the ninth leading cause of cancer deaths in the United States.
Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV)
infections account for an estimated 78% of global HCC cases. To
determine trends in HCC incidence in the United States, CDC
analyzed data for the period 2001--2006 (the most recent data
available). The average annual incidence rate of HCC for
2001--2006 was 3.0 per 100,000 persons and increased
significantly from 2.7 per 100,000 persons in 2001 to 3.2 in
2006, with an average annual percentage change in incidence rate
of 3.5%. The largest increases in HCC incidence rates were among
whites and persons aged 50--59 years. Development of viral
hepatitis services, including screening with care referral for
persons chronically infected with HBV or HCV, full
implementation of vaccine-based strategies to eliminate
hepatitis B, and improved public health surveillance are needed
to help reverse the trend in HCC.
Read full report:
CDC MMWR
Improved Hep B Outcomes After Liver Transplant
A report from the Mayo Clinic stated that
treatment to reduce the recurrence of hepatitis B appears to
improve liver transplant outcomes. Hepatitis B infection is a
major cause of liver damage that can eventually lead to
end-stage liver disease and the need for a liver transplant. New
medications that include antiviral therapy and hepatitis B
immune globulin to reduce the risk of recurrence have improved
outcomes. In the past, hepatitis B has recurred in transplant
patients, causing severe liver damage and the need for a second
transplant. The study showed that in patients with HBV, the
number of people listed for a second transplant within three
years decreased by fifty percent between 1996 and 2005.
Read more:
Science Daily
New
York Needs Organ Donors!
According to the director of the Rochester-finger
Lakes Eye and Tissue Bank, Linda Fraser, the need for
life-saving transplants is dire in New York State, but the
number of eligible people actually registered as organ donors is
significantly lower than most states. As of 2009, only 13
percent of eligible New Yorkers were registered to be donors
(the age requirement to donate is 18 and up), while in other
states such as Alaska, the number is as high as 70 percent.
Fraser attributes these low numbers to the fact that New York is
one of the few states that does not permit organ donor
registration online-most people register through the DMV when
obtaining or renewing their driver's license. In addition, there
are many misunderstood principles associated with organ
donation. Most people do not understand the intricacies of such
a procedure unless there has been a need in the family for a
transplant.
Read more:
City News
Semen Unlikely
to be Reason For Sexually-Transmitted HCV
A new study has revealed that the hepatitis C
virus is detectable in the semen of a minority of HIV-positive
gay men co-infected with both viruses at very low levels,
indicating that transmission of hepatitis C during sex is via
blood, not semen. These findings are leaving researchers looking
for an explanation as to why HIV-positive men are estimated to
be 50 times more likely to acquire HCV than HIV-negative men.
The study recruited men from the HCV cohort at Mortimer Market
in London.
Read more:
AIDs Map News
Hepatitis C Infection Doubles
Risk for Kidney Cancer
Physicians at Henry Ford
Hospital have found that Hepatitis C infected patients had
nearly double the risk of developing kidney cancer, after
assessing age, gender, race, and underlying kidney disease.
These results show that the hepatitis C virus causes disease
that extends beyond the liver, and in fact most of our
HCV-infected kidney cancer patients had only minimal liver
damage. This
establishes the need for a more careful surveillance of newly
diagnosed kidney cancer patients for the presence of hepatitis C
infection, one of the few cancers with a rising global
incidence.
Read more:
Health News Digest
New Drug Cures Hard-to-Treat
Hepatitis C
Telaprevir is one of two highly
anticipated drugs in the class known as protease inhibitors
being studied in patients with chronic hepatitis C infection, a
condition that affects about 3 million Americans and is the
leading cause of liver transplants in the U.S. About 40% of
previously untreated HCV patients are cured with the current
treatment regimen, which includes 48 weeks of peginterferon and
Ribavirin. A second round of treatment is often recommended for
patients who fail to respond to initial treatment or who respond
and then relapse. When the drug telaprevir was added to standard
treatment with peginterferon Alfa and Ribavirin, which are also
antiviral, about half of patients who had failed previous
treatment with the two drugs cleared the virus.
Read more:
WebMD
Liver Test For
Kids Inaccurate
A new study shows that the routine screening test
used to detect liver problems in children is being interpreted
differently across the nation, allowing many cases to go undetected. The study
at the University of California, San Diego, School of Medicine has been
revealed that the common screening test for chronic liver disease that
uses serum alanine aminotransferease (ALT) is using different values
to detect risks for kids
across many of the nation's children's hospitals.
The children were placed in four groups to a new limit of normal ALT:
children with normal livers; with chronic hepatitis B virus; with
hepatitis C virus; and children with non-alcoholic fatty liver disease. The study
revealed only one-third to one-half of children with liver disease would
be detected by the old standards and that the new values established by
the study would improve detection to 70 to 80 percent.
Read more:
Children's Health Channel
HCV Therapy Fails in Many Urban Patients
The standard treatment for hepatitis C, which is
highly effective in clinical trials, may be unavailable,
inappropriate, or ineffective in urban U.S. patients. In
clinical trials, treatment with Pegylated Interferon and
Ribavirin, yielded sustained viral response rates between 54%
and 63%. But in an urban population, with many members of ethnic
minorities, sustained viral response rates were between 14% and
37%. The study also confirms that members of ethnic minorities,
who are usually under-represented in clinical trials, do not
fare as well as expected with treatment in the real world.
Physicians need to know not only the efficacy of combination
therapy as demonstrated in phase III registration trials, but
also its effectiveness: the outcome of treatment in patients
like their own receiving ordinary clinical care.
Read more:
MedPage Today
Tattoo Shops
Regulations Tightened
The San
Bernardino County Board of Supervisors unanimously voted to
support legislation that would tighten up regulation of
oversight of businesses that provide tattooing, body piercing
and permanent cosmetic application services. The Safe Body Art
Act would establish minimum statewide health and oversight
standards for tattoo parlors and body art businesses. The
absence of statewide regulations and standards puts public
health at risk by increasing the threat of blood-borne diseases,
particularly Hepatitis C and HIV.
Researchers
at the Centers for Disease Control and Prevention have linked
clusters of antibiotic-resistant skin infections to unlicensed
tattoo artists who didn't follow proper sterilization and needle
disposal procedures.
Read more:
http://www.sbsun.com/sports/ci_14687937#ixzz0iRwr2fZg
20 PERCENT OF AT-RISK
NEWBORNS ARE NOT RECEIVING PREVENTATIVE
HEPATITIS B VACCINE AND
TREATMENTS, STUDY REVEALS
March 12, 2010, 01:03 pm
Approximately 20 percent of infants born to
mothers with hepatitis B are not receiving the proper
preventative treatments, researchers at the U.S. Centers for
Disease Control and Prevention (CDC) found in a recent study
published in the April 2010 issue of Pediatrics. Infants who
receive the hepatitis B vaccine and hepatitis B immunoglobulin
(an injection of hepatitis B antibodies) are 85 to 95 percent
protected from the disease. CDC researchers examined medical
records of 4,762 mothers and 4,786 infants, with 18 women
testing positive for hepatitis B upon admission to the hospital.
According to CDC epidemiologist and study author
Bayo Wills, transmission of hepatitis B is almost entirely
preventable through vaccination and proper medical procedures
created to protect people from the disease. "We really need
hospitals to have correct policies in place and to implement
those policies so that every newborn is protected before they
leave the hospital," said Willis. Recommendations provided by
the CDC state that newborns should receive the hepatitis B
vaccine at birth, followed by booster shots at one and six
months old. Of the 190 hospitals examined in the study, only 67
percent had a policy in place to ensure hepatitis B vaccination.
"The greatest predictor of which children would get the
hepatitis vaccine was the hospital having a policy for universal
vaccination of infants. Our study shows that gaps still persist
in perinatal hepatitis prevention," added Willis.
Though 62 percent of the infants of hepatitis
B-positive mothers received the proper hepatitis B vaccination
and immunoglobulin, approximately 14 percent of the newborns did
not receive the vaccination, while nearly 20 percent did not
receive the injection of hepatitis B immunoglobulin before
leaving the hospital. Approximately 52 percent of babies born to
an additional 320 women with an unknown hepatitis B status
received the hepatitis B vaccine within 12 hours of birth, while
20 percent of the infants left the hospital unvaccinated.
Additional information about drugs and drug side effects [1] may
be found on DrugWatch.com.
Miss Apple Blossom Takes Liver
Messages to School
Shannon
Beam, Miss Apple Blossom Festival 2010, has joined
Hepatitis Foundation International as a spokesperson, taking
important liver health messages to Virginia public schools. Shannon, who will be competing for the title of Miss Virginia this
summer, will be integrating key ideas from HFI's unique
approach towards liver wellness and preventing unhealthy
behaviors into her work of teaching students about the
negative effects of alcohol and drug use on the liver.
CEO Receives Lifetime Achievement
Award
On March 7 and 8, 2010, the Digestive Disease National
Coalition
(DDNC) held its 20th Annual National Public Policy
Forum in Washington, DC. Thelma King Thiel, Chair and CEO of
Hepatitis Foundation International, was awarded the Lifetime
Achievement Award for her contributions to the DDNC as one of
the co-founders of the coalition. Members of 125 organizations
were in attendance to applaud Thelma for her efforts in
influencing legislators with regard to health policy and
funding.
After forty years of hard work and dedication to the
cause,
Thelma continues on with her mission to promote awareness
about liver disease prevention and to educate the public on
how
to take responsibility for their own health care.
Thelma has influenced people all over the world throughout the
years with her charming and witty presentations that healthcare
providers and “regular folks” alike can relate to. The award
recognizing her support for the digestive disease activist
community was presented to Thelma by the DDNC's Chairperson
Linda Aukett.
New
Drug Impacts Encephalopathy.
Salix Pharmaceuticals Ltd. has reported that the FDA's
Gastrointestinal Drugs Advisory
Committee has approved XIFAFAN, a medication for the treatment of hepatic
encephalopathy (HE). HE is a neurological disorder that is caused by
chronic liver failure
resulting in cognitive, psychiatric, and motor impairments. Patients with
cirrhosis develop
this condition which involves neuropsychiatric abnormalities caused by
the liver's inability
to remove toxic products from the blood, such as ammonia producing
bacteria. Cirrhosis
is typically caused by alcohol and drug abuse, chronic viral hepatitis,
and autoimmune
disease and is also a leading cause of death in the US. XIFAFAN is the
first potential
treatment option for patients with HE, giving new hope to over 200,000
Americans who
suffer from this debilitating disease.
http://www.biospace.com/news_story.aspx?NewsEntityId=171516
Paper "Chips" for Diagnosis of HIV and Hepatitis Could Provide
Cheap Diagnosis
of HIV and Hepatitis and other diseases
A Harvard University chemistry professor has developed a
prototype for a small "paper
chip" that may serve as a cheap and accessible way for people to diagnose
diseases
from their own homes. The chip works by placing a drop of blood onto a
small square
piece of paper filled with water-repellent ink, which then funnels the
blood into different
channels creating a colored pattern shaped like a tree on the opposite
side. By analyzing
the ink's color and distribution, a person would be able to diagnose a
number of diseases
such as malaria, HIV, Hepatitis, and gastroenteritis as well as the level
of infection. This
cost efficient technology is expected to radically change health care in
developing
nations.
http://www.switched.com/2010/02/25/paper-chips-could-provide-cheap-diagnosis-of-hiv-and-hepatitis/
Travel Clinic Prepares Students
for Spring Break Abroad:
West Virginia University's International Travel
Clinic has taken up the initiative to educate students on the
health risks associated with certain travel destinations that
students may visit during their spring break vacations. As many
students will be traveling abroad this spring, the travel clinic
is available for student inquiry about immunizations via
personal appointment and phone consultations. Healthcare
employees at the clinic recommend that students be immunized for
Hepatitis A, Hepatitis B, and tetanus before going abroad. The
travel clinic uses recommendations set forth by the
International Association of Medical Assistance to Travelers, an
organization that combines the efforts of the Center for Disease
Control, the World Health Organization, and state departments
across the US.
http://www.thedaonline.com/news/travel-clinic-prepares-students-for-spring-break-abroad-1.1171315
Hepatic Steatosis in Hepatitis C
is a Storage Disease Due to HCV Interaction With Microsomal
Triglyceride Transfer:
Liver steatosis, a condition that develops due to
a degeneration of lipids within liver cells is common in
patients with chronic Hepatitis C. New research shows that the
relationship between the virus and steatosis is the result of
both epigenetic and genetic factors. The study found that
Hepatitis C can alter standard lipid metabolism within the liver
because of an interaction between the virus and MTP. Based on
these results, researchers concluded that steatosis associated
with hepatitis C could be a storage disease induced by the
effects of the virus and may cause more persistent infection in
persons with HCV.
http://www.nafwa.org/nafwa-library/129-free-full-text-articles-and-books/3577-hepatic-steatosis-in-hepatitis-c-is-a-storage-disease-due-to-hcv-interaction-with-microsomal-triglyceride-transfer-protein-mtp
Reliable Biomarker Needed to
Improve Diagnosis Methods of Liver Cancer
Dr. Anna S. Lok of the University of Michigan
Medical Center has recently published the results of a study on
biomarkers in the diagnosis of liver cancer. Liver cancer is the
third most common cause of cancer-related deaths worldwide and
its increasing prevalence in the US is largely attributed to
cases of Hepatitis C. Currently, ultra-sonography is the
preferred surveillance method for liver cancer, but many cases
are not detected until later stages of progression. Lok's study
showed that serum indicators varied by patient demographics, a
factor that may be integral in improving this method of
diagnosis for liver cancer, preventing late-stage diagnosis and
saving lives.
http://www.eurekalert.org/pub_releases/2010-02/aga-rbn022510.php