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Thelma King Thiel, RN, BA
Chair and CEO
Hepatitis Foundation International


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Public Service Announcement

Our hepatitis prevention public service announcement is now online and available for download. Click Here
 

Press Releases


Hepatitis Foundation International Delivers Activities to Support Take Your
      Children to Work Day


U.S. Expert Promotes Hepatitis Prevention at WHO Meeting in Italy

HFI CEO Represented USA at European Liver Meeting
 

Give Your Liver a Break DVD Wins Emmy

 

Breaking News
 


Proposed Federal Funding for 2012

Legislators are considering supporting this proposed funding package for 2012.

  • $588.94 billion for the Department of Health and Human Services, which is an increase of $15.1 billion over FY 2011 and $3.66 billion less than the president’s request.

  • $6.12 billion for the Centers for Disease Control and Prevention (CDC), a decrease of $157 million from FY 2011  and $269 million less than the president’s request.

  • $33.48 billion for the Substance Abuse and Mental Health Services Administration (SAMHSA), a decrease of $27  million from FY 2011 and $72.69 million less than the president’s request.

  • $30.7 billion for the National Institutes of Health, an increase of $300 million over FY 2011 and $58 million less than the president’s request.

  • $71.28 billion for the ‘department of education, a decrease of $kk151.1 million from FY 2011 and $9.25 billion below the president’s request.

  • $53.12billion for the Veterans Health Administration, an increase of $1.98 billion over  FY 2011 and $72.23 million more than the president’s request.

  • $6.48 billion for the Health Resources and Services Administration, a decrease of $41 million from FY 2011 and $850 million less than the president’s request.

It is anticipated that this will be approved and signed by the president shortly.

 

 

 

Hepatitis Foundation International Call to Action for World Hepatitis Day: Get Tested, Get Immunized, and Help Prevent New Infections.

 

Hepatitis Foundation International, dedicated to liver health and the prevention of liver related diseases, urges people to get tested and immunized to help prevent new viral hepatitis infections.

“We have the power to prevent new hepatitis infections, whether hepatitis A, B or C, through immunizations, avoiding risky behaviors such as sharing needles, toothbrushes and razors, and encouraging those as risk for infection to get tested,” said Thelma King Thiel, CEO and Chairman, HFI.

 

The goal of World Hepatitis Day was  to increase awareness of viral hepatitis and the diseases that it causes. Viral hepatitis is a significant burden across the globe accounting for:

  •     130 million people chronically infected with hepatitis C;

  •     An estimated 2 billion people worldwide infected with hepatitis B;

  •     1.4 million cases of hepatitis A annually.
     

In the United States, chronic hepatitis C and hepatitis B infections continue to persist while hepatitis A infections have been dramatically decreased due to increased awareness and hygiene. Because viral hepatitis can persist for decades without symptoms, 65%-75% of infected Americans remain unaware of their infection status and are not receiving care and treatment. In May of this year the Department of Health and Human Services issued the National Viral Hepatitis Action Plan to prevent disease and help those who are diagnosed.
 

HFI knows of the urgency to make this action plan happen, especially the need to identify the large at-risk population of Baby Boomers, who are likely unaware of their infection. HFI urges people to take the following steps to prevent hepatitis and preserve their liver:

  1. Get tested. For information about testing contact your local public health
    department or your doctor.

  2. Get vaccinated. Vaccinations for hepatitis A and B are available.

  3. Get educated and protect your liver. The liver is vital for overall health. Avoid
    drugs, alcohol and limit the amount of fatty, unhealthy foods, all of which damage the liver.

About Hepatitis Foundation International
The mission of the Hepatitis Foundation International is to promote liver wellness, healthy lifestyles, and reduce the incidence of preventable diseases that affect the liver including obesity, diabetes, fatty liver, hepatitis, HIV, and substance abuse. For information visit http://www.hepatitisfoundation.org.


Carrie Sessine
Graceful PR   
(202) 618-0567


 

New Liver-Like Cells Enhance HCV Research
 

Researchers at MIT, Rockefeller University and the Medical College of Wisconsin have found a way to create liver-like cells from induced pluripotent stem cells (iPSCs), which are made from body tissues rather than embryos. These liver-like cells can then be infected with hepatitis C. Studying liver cells from various people could reveal genetic factors to enhance efforts to understand why some people are resistant to hepatitis C, while others are highly susceptible to this infectious disease.

Along with benefiting hepatitis C research, the new technique may eventually have a role in personalized medicine, the researchers said in a MIT news release. By testing the effectiveness of different drugs on tissues derived from a patient, doctors may be able to customize therapy for patients.
 


 

Drug Induced Liver Injury
 

Drug-induced liver injury is the most common cause of acute liver failure in the US with overdoses of acetaminophen identified as the most frequent cause of liver injury. . Liver toxicity limits the development of many therapeutic compounds and presents major challenges to both clinical medicine and to the pharmaceutical industry causing abandoning drugs early in development or withdrawal from the market. Currently, no pharmaceutical strategies exist for preventing drug-induced liver injury and treatment options are limited to discontinuing the offending drug, supportive care, and transplantation for end-stage liver failure.

Suraj Patel, a postdoctoral researcher at Massachusetts General Hospital and Marti Yamush at Rutgers have developed a clinically viable strategy that targets a liver’s gap junctions—hollow multimolecular channels that connect neighboring cells and allow direct communication between coupled cells. They have shown that gap junctions spread immune signals from injured liver cells to surrounding undamaged cells, amplifying inflammation and injury. The current study examined inhibiting the action of liver-specific gap junctions to limit drug-induced liver injury. Much more needs to be known about any off-target effects of gap junction inhibitors and better understand the long-term ramifications of temporarily blocking liver-specific gap junction channels before applying this approach to patients, according to Dr. Patel.

 

Childhood Obesity- Thousands at Risk
 

Doctors in the U.K say obesity levels are now so high that children are commonly suffering signs of disease more commonly associated with alcohol abuse, meaning many will go on to develop cirrhosis, with some requiring liver transplants.
 

Government estimates say around 500,000 children below the age of 15 are suffering from “non alcoholic liver disease” which is caused by a build-up of fat within liver cells.

The condition increases the risks of heart disease, strokes and type 2 diabetes, and can lead to cirrhosis-scarring of the liver-which is often not detected until it is too late. Thousands of lives are already at risk.
 

Prof. Martin Lombard, the Department of Health’s national clinical director for liver disease warned that the disease was rarely detected until it had caused damage. He said “Liver disease is a killer, which is putting the lives of thousands of our children at risk. We do not want to see the next generation dying young from a condition that can be prevented.”
 

Prof Lombard said he was concerned that children suffering from fatty liver disease were at particular risk if they started experimenting with alcohol in teenage years. He said even modest amounts of alcohol could worsen the condition. There is no medical treatment for the disease, but the extent of it can be reduced by weight loss and improvements in diet. Young people who are over weight or obese need to make simple changes to their lifestyle.

 

 

 

Are You Feeding Your Heart Too Much Mayo??

 

What does the heart have to do with mayonnaise, grease and cheese??? A recent article by Web MD titled Do Your Heart a Favor: Avoid These Appetizers identified some good and bad choices.

 

To help you make good choices, we’d like to connect the heart with the food you eat. . . and your liver that processes the food (fuel) you feed it that keeps you alive and functioning 24/7.

 

Loading up your liver with fats, too much sugar and carbohydrates can not only clog up your arteries, they can damage your liver . . .your internal chemical converter and energy source.

 

Did you know that almost everything you eat has to be processed by your liver?  Clogging it up with too many fatty foods can compromise this process. One in 6 Americans has a fatty liver that can lead to cirrhosis.

 

When you learn you have high cholesterol, what is the first thing you are told to do?

Change your diet!!!  Did you know that your  liver is responsible for the production and

excretion of cholesterol? What are you eating that is helping your cholesterol

go through the roof?

 

Learn how to take care of liver. Visit www.PartnersinLiverWellness.org

 


Mental Confusion;  Is it Alzheimer’s or Cirrhosis??
 

Most of us are well aware of the signs of mental confusion related to Alzheimer’s Disease.  However, cirrhosis and liver failure can cause similar symptoms due to the liver’s inability to remove or process toxins ingested in food, drugs and alcohol, and those made in the body. These toxins remain in the blood and are carried to the brain where they affect cognition.

 

Several liver related diseases can lead to cirrhosis including: fatty liver, viral hepatitis, autoimmune hepatitis, Wilson’s disease, and alcohol abuse, and many others.

 

Most people do not think of obesity as a liver problem; however, two-thirds of Americans are overweight without a clue that overeating and eating too many fatty foods can lead to cirrhosis of the liver.

 

Almost everything you eat, breath and absorb through your skin must be processed through you liver.

 

Liver transplants are very expensive,  Changing your diet and protecting your liver is a cost effective way to (be a long liver) live a longer and healthier life.    

 

 

 

HCV Infected?  Protecting Your Liver

 

An increasing number of chemicals in pesticides, aerosols, cleaning agents, waxes and lacquers and other pollutants in  the environment are leading to liver damage. The liver is the primary organ in the human body that metabolizes foreign compounds such as drugs, alcohol, cigarette smoke and environmental chemicals including those on the foods we ingest. It needs your help when it is struggling with hepatitis B or C infections.

 

There is a lack of comprehensive understanding of the cell-and organ-wide effects of mixtures of toxic substances and how interactions among them can lead to increased liver damage. Much more research is needed to prevent or mitigate life-threatening toxicant-induced liver health issues. Until then be sure to wash fruit and vegetables before eating them; have proper ventilation when using sprays and/or wear a mask; and cover your skin and wash it thoroughly if exposed to weed killers, bug sprays,

paint thinners, or other chemicals used in and around your house.

 

Words to live by;  Almost everything you eat, breathe or absorb through your skin has to be processed and detoxified by your liver. Your liver is your silent partner  that depends on you to protect it from harm. 

 

 

 

HFI Jump Starts Viral Hepatitis Action Plan.

 

The Hepatitis Foundation International (HFI) applauds  the U.S. Department of Health and Human Services (HHS) for its Action Plan to Prevent, Care and Treat Viral Hepatitis, a silent and underestimated public health problem. Implementation of the plan depends on government support to be effective. HFI knows of the urgency to make this action plan happen, especially the need to identify the large at-risk population of Baby Boomers of whom many are unaware of their infection. For many years the Foundation has developed programs and worked to engage healthcare providers, and community and corporate leaders to promote liver health/wellness programs and empower individuals to assess their own risk of infection, seek testing and take advantage of new treatments and subsequent cures.

 

To promote liver health education, missing in most prevention programs, HFI continues to reach and engage leading organizations including Georgia Power/Southern Company and The Coca Cola Company to join Partners in Liver Wellness, HFI's initiative to encourage liver health education in the workplace.
 

Georgia Power/Southern Company, who was impressed with HFIs liver health program that promotes healthy lifestyle behaviors and avoidance of liver damaging activities, provided the liver health information to its 9,000 employees through their Safety Education Program.  Their medical director, Dr. Rob Harshman said, “ I am happy to hear there is growing momentum to educate people in protecting their livers through healthy lifestyles. It is a message we have to continually revisit.”

  

“We can not afford to wait until people get sick.  Understanding  the important role the liver plays is essential to enable individuals to avoid liver related debilitating chronic illnesses that include hepatitis, fatty liver, obesity, diabetes and alcohol and drug misuse and abuse”, says Dr. Raymond Koff, hepatologist and clinical professor  at University of Connecticut  Health Sciences Center.

 

Prevention depends on individuals making personal healthy lifestyle choices.  Education is the key.   

 

 

 

Alarming Increase of HCV Among Young Adults

 

A report from the Massachusetts Department of Health showed an alarming increase in the rate of Hepatitis C Infection among young adults age 15 – 24. This was nearly double the rate between 2002 and 2009. According to state officials, this new wave of disease is attributed to the rise in abuse of Percocet and oxicodone leading to participation in intravenous drugs  use by young adults, The increase is purported to be linked to sharing infected needles to inject the drugs.

 

“We can not afford to wait until young adults are infected to address this increasing health problem,” comments Dr. Raymond Koff, hepatologist and clinical professor at Connecticut University Health Sciences Center. “Educating children at an early age

about the important role the liver plays and how drugs and alcohol can impact their health and life itself is essential to empower young people to make informed choices and avoid the life altering impact of being hepatitis C infected.” 

 

Absent in most primary and secondary school curricula is information about liver health and adoption of healthy lifestyle behaviors. Extensive surveys by the Hepatitis Foundation International (HFI) show that the majority of teachers lack the knowledge and teaching tools to engage their students in avoiding liver damaging behaviors. Prevention of hepatitis C and other liver related diseases can save lives

and healthcare dollars. HFI’s Partners in Liver Wellness educational initiative is recognized nationally for its leadership in promoting liver health and healthy lifestyles. For information and participation in promoting liver health call 1-800-891-0707

 

 

 

Two New Drugs Provide Hope for More Cures

 

The U.S. Food and Drug Administration (FDA) has approved two new drugs; telaprevir (Incivek, Vertex) and boceprevir  (Victrelis, Merck) to be used with peginterferon plus ribavirin for the treatment of Hepatitis C virus (HCV) infection, thereby providing new hope for patients who are infected. Both drugs are serine protease inhibitors and cannot be used as monotherapy.

 

Telaprevir is approved for the treatment of chronic hepatitis C genotype 1 infection, in combination with peginterferon and ribavirin, in patients aged 18 years and older with compensated liver disease, including cirrhosis, who are treatment-naive or who have been previously treated with interferon-based treatment. Patients who received 750 mg of telaprevir every 8 hours with meals along with the conventional treatment of peginterferon plus ribavirin had a significantly higher rate of sustained virologic response (SVR) of 79%, considerably higher than the rate observed in patients receiving conventional therapy. The SVR response rate for all patients across all studies and all patient groups, was 20% to 45% higher than the current standard of care. Treatment with telaprevir is limited to 12 weeks with peginterferon plus ribavirin, and then the peginterferon and ribavirin are continued for an additional 12 weeks for a total of 24 weeks of treatment in most patients. Some patients, about 40%, with require longer therapy with peginterferon and ribavirin. Patients who had relapsed from prior therapy achieved a SVR of 86%, while those with a partial response had a SVR of 59% and so-called null responders had the lowest SVR of 32%. Anemia was a common adverse event and serious skin reactions with telaprevir occurred in less than 1% of patients.

 

Boceprevir, also approved for the treatment of genotype 1 chronic hepatitis C patients with compensated liver disease, including cirrhosis, who are over 18 years of age, is given four weeks after beginning the combination of peginterferon plus ribavirin in a lead-in phase. The dose of 800 mg is given orally with food every 7 to 9 hours. Boceprevir may given for 24 weeks together with peginterferon plus ribavirin, following the four-week lead-in phase, in about 45% of patients, and for 44 weeks in the remainder, based on HCV RNA levels measured at weeks 8 and 24. For naive patients, SVR was achieved in 63-66% of patients.  Patients who previously had relapsed or had a partial response when treated with peginterferon and ribavirin, achieved a SVR of 70-75% and 40-52%, respectively. Null responders, defined as individuals in whom HCV RNA levels failed to decline by at least 2 logs at week 12 of previous treatment were not included in Phase III studies but in earlier studies, SVR rates were less than 15%..Adverse effects of concern include: anemia, neutropenia and thrombocytopenia but serious skin reactions were not seen.

 

As with conventional treatment, patients need to be warned that both treatment regimens have the potential to cause depression, suicidal ideation and, if taken during pregnancy, birth defects. Because of drug-drug interactions, it is essential that all medications be carefully reviewed before beginning either therapy

 

 

Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH)
 

Fat accumulation in the liver in individuals who do not drink alcohol, is called nonalcoholic fatty liver disease (NAFLD).  As a consequence of the on-going obesity epidemic in the U.S., fatty liver is a very common disorder with an estimated two thirds of obese adults and half of obese children having fat accumulation in the liver. Up to 20% of those who are obese may suffer from a more severe condition called non-alcoholic steatohepatitis, (NASH). This occurs when fat build up in the liver is associated with liver cell inflammation and various degrees of liver cell death called cirrhosis. In many of those affected by NAFLD, obesity may be the only warning of a fatty liver. Some people may have a slightly enlarged liver, feel tired and have some abdominal pain.  However, fatty liver is suspected when a blood test of specific liver enzymes (serum aminotransferease enzymes) is elevated in an individual who is obese. Fatty liver can be confirmed by an ultrasound examination of the liver or by liver biopsy.
 

Read more: NAFLD Article

 



HFI Launches Partners in Liver Wellness Initiative
 

  The Hepatitis Foundation International hosted the 
 launch of its Partners in Liver Wellness initiative in Atlanta, Georgia.  Partners in Liver Wellness is a call to action to  address the rising tide of preventable liver diseases, including hepatitis, fatty liver disease, and drug use and abuse and alcohol-related liver disease among America’s workforce
. By enlisting leaders from the corporate and public health communities this national initiative will help employers promote liver health/wellness filling the enormous knowledge gap in liver health education. Our goal is to save lives and reduce healthcare costs by empowering individuals to understand the importance of the liver in maintaining healthier, more productive lives. 
  
Former NFL Coach Dan Reeves, co-chair of this initiative, reported that “Listening to a presentation on the importance of the liver had the greatest impact on my teams motivating them to take care of themselves and avoid the pitfalls of participating in liver damaging  behaviors. We need to reach out to our community leaders to help our children, families and employees take responsibility for their own healthcare and adopt healthier lifestyles”
  
HFI is conducting a series of Partners in Liver Wellness
meetings to bring these importance awareness messages
to communities across the nation. For more information:
call Thelma King Thiel at 1-800-891-0707.

 

 

The Influence of NAFLD and Its Associated Co-morbidities on Liver Transplant Outcomes

Non-Alcoholic Fatty Liver Disease is a rising epidemic in the US, fueled in part by the dual epidemics of obesity and diabetes. As NAFLD increases in incidence and prevalence, researchers expect it to become the leading indication for liver transplantation in the next two decades. The abstract of a new study from the University of North Carolina, Chapel Hill was presented at Digestive Disease Week, May 1-5 in New Orleans, LA. The study found that NAFLD is significantly associated with worse transplant outcomes (death and graft failure) within the first 30 days after a liver transplant. The study, which observed 118 liver transplants in a three-year period, is based on previous research published in 2009 that reached similar conclusions.


Read more: DDW 2010


 

Antiviral ‘Cocktail’ Better than Single Drug for Children with Hepatitis
 

An estimated 132,000 U.S. children are infected with the Hepatitis C virus, and nearly 42,300 of them are chronically infected. Children receiving the combination therapy of PEG interferon injections and the antiviral drug Ribavirin cleared the infection at a rate of two and a half times greater than children receiving PEG interferon treatment alone according to a study conducted by Johns Hopkins Children Center. Viral clearance occurs when the blood is free of viral traces at the end of the treatment, and sustained viral clearance occurs when the blood remains clear for at least six months after stopping treatment. Full clearance is the hallmark of effective therapy and was where the greatest differences between the two treatments emerged. The study showed that combination therapy proved more effective in clearing the Hepatitis C virus in children ages 5-17, and children receiving the combination therapy were less likely to relapse after stopping treatment, with only 17 percent compared to the 45 percent of children on the single-drug approach. 
 

Read more: Johns Hopkins Children's Center

 


Spice in Curry Could Prevent Liver Damage

Curcumin, a spice regularly found in curry and contained in the Tumeric plant could serve as a natural way to help prevent and treat liver damage caused by fatty liver disease.  Fatty liver disease, linked to obesity and weight gain, affects an estimated 3 to 4 percent of the US population and if left untreated can lead to cirrhosis, liver cancer and even death. Research has shown that obese patients typically have higher levels of blood leptin, glucose and insulin, all of which might contribute to liver fibrosis, the scarring of the liver.  Elevated levels of leptin activate hepatic stellate cells, which in turn overproduce collagen protein, a major factor of liver fibrosis.  Preliminary research released by Saint Louis University suggests that Curcumin minimizes the effects of leptin on activating hepatic stellate cells, which in turn helps to lessen the development of liver damage. 


Read More: Science Daily


 

Childhood Obesity- Impact of Liver Transplant

Studies show that obesity has a significant negative impact on pediatric patient survival more than 5 years post-liver transplant.  A study examined the impact of pre-transplant Body Mass Index (BMI - a measure of someone’s weight in relation to their height) on post liver transplant survival in the pediatric population.  Results indicated children who were thin or severely thin had a significantly lower survival (84%) at one year compared to the survival (89%) of children in the normal and overweight groups.  However by the 12th year following liver transplant, those in the obese group had significantly lower survival (72%) than the survival (77%) of normal or overweight pediatric patients.  The study conducted by the University of Washington concluded that identifying pre and post transplant pediatric patients as malnourished or obese along with optimization of their modifiable risk factors will help maximize patient survival by better utilizing scarce donor organs. 


Read More: Science Daily




Liver Hormone is a Cause of Insulin Resistance

The hormone, Selenoportein (SeP), produced and secreted by the liver was previously an unknown cause of insulin resistance. Research shows that the livers in people with type 2 diabetes who are more insulin resistant express higher levels of gene encoding Selenoportein P (SeP). Blood levels of SeP are also increased in people with diabetes compared to healthy people. This finding suggests a new target for the treatment of insulin resistance and type 2 diabetes. This study published by Kanazawa University Graduate School of Medical Science in Japan further shows there may be other hormones derived from the liver with important and varied roles in the body.


Read More: Physorg.com



 

New Serum Marker for Hepatocellular Carcinomaa

New findings have shown that the combined measurement of golgi protein 73 (GP 73) and alpha-fetoprotein (AFP) increased the sensitivity for hepatocellular carcinoma (HCC). GP73 decreased following surgical resection of HCC lesions and increased with tumor recurrence. Non-liver cancers in 14 organs (colon, rectum, stomach, esophagus, pancreas, lung, thyroid, kidney, bladder, prostate, breast, ovary, cervix and endometrium) were analysed.
 

In conclusion, the authors submitted that GP73 is an accurate serum marker for the detection of hepatocellular carcinoma (HCC) and its recurrence after surgery. It had a higher sensitivity and specificity than alpha-fetoprotein (AFP). Also, they recommended clinical implementation of serum GP73 measurement as a standard test for hepatocellular carcinoma (HCC)


Read More: GUT Online

 

 

FDA Considers Expanded Use of HCV Drugs

The FDA is considering the establishment of a compassionate use program that would allow severely ill hepatitis C (HCV) patients access to investigational, direct-acting antiviral agents. This effort to control Hepatitis C more effectively is in response to a petition by groups seeking access to the drugs for individuals often excluded from clinical trials, which are only open to a small subset of real-world HCV patients. Many patients are rejected from clinical trials due to co-morbidities, drug use, and mental illnesses. Check out the rest of the article, which features commentary from Dr. Diana Sylvestre, a speaker at HFI's Viral Hepatitis Summits:


Read More: MedPage Today

 




Many Kids with Hepatitis C are Missed

Many children with hepatitis C go undiagnosed and untreated, which can lead to severe liver damage later in life. National data shows that between 0.2 percent and 0.4 percent of children in the United States is infected with hepatitis C. Most children and adults infected with hepatitis  C do not have symptoms or they may have fatigue or abdominal pain. This results in the lack of proper identification. Most young children get the infection from their mothers while in the womb, which accounts for about 60 percent of the infections in young children. Teenagers can get it through IV drug use and other substance abuse. Unfortunately, there is a widespread lack of awareness of the condition and adequate screening is not often done. Moreover, children are too often not referred to treatment. Early identification of pediatric hepatitis C infection would likely help us cure the infection in over 50 percent of children that currently have it.

 
Read more: U.S. News Health

 

Deadly Cancer is Preventable

Liver cancer, or hepatocellular carcinoma (HCC), is the third leading cause of death from cancer worldwide and the ninth leading cause of cancer deaths in the United States. Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for an estimated 78% of global HCC cases. To determine trends in HCC incidence in the United States, CDC analyzed data for the period 2001--2006 (the most recent data available). The average annual incidence rate of HCC for 2001--2006 was 3.0 per 100,000 persons and increased significantly from 2.7 per 100,000 persons in 2001 to 3.2 in 2006, with an average annual percentage change in incidence rate of 3.5%. The largest increases in HCC incidence rates were among whites and persons aged 50--59 years. Development of viral hepatitis services, including screening with care referral for persons chronically infected with HBV or HCV, full implementation of vaccine-based strategies to eliminate hepatitis B, and improved public health surveillance are needed to help reverse the trend in HCC.

 

Read full report: CDC MMWR

 

Improved Hep B Outcomes After Liver Transplant

A report from the Mayo Clinic stated that treatment to reduce the recurrence of hepatitis B appears to improve liver transplant outcomes. Hepatitis B infection is a major cause of liver damage that can eventually lead to end-stage liver disease and the need for a liver transplant. New medications that include antiviral therapy and hepatitis B immune globulin to reduce the risk of recurrence have improved outcomes. In the past, hepatitis B has recurred in transplant patients, causing severe liver damage and the need for a second transplant. The study showed that in patients with HBV, the number of people listed for a second transplant within three years decreased by fifty percent between 1996 and 2005.


Read more: Science Daily

   

New York Needs Organ Donors!

According to the director of the Rochester-finger Lakes Eye and Tissue Bank, Linda Fraser, the need for life-saving transplants is dire in New York State, but the number of eligible people actually registered as organ donors is significantly lower than most states. As of 2009, only 13 percent of eligible New Yorkers were registered to be donors (the age requirement to donate is 18 and up), while in other states such as Alaska, the number is as high as 70 percent. Fraser attributes these low numbers to the fact that New York is one of the few states that does not permit organ donor registration online-most people register through the DMV when obtaining or renewing their driver's license. In addition, there are many misunderstood principles associated with organ donation. Most people do not understand the intricacies of such a procedure unless there has been a need in the family for a transplant.


Read more: City News

 

Semen Unlikely to be Reason For Sexually-Transmitted HCV

A new study has revealed that the hepatitis C virus is detectable in the semen of a minority of HIV-positive gay men co-infected with both viruses at very low levels, indicating that transmission of hepatitis C during sex is via blood, not semen. These findings are leaving researchers looking for an explanation as to why HIV-positive men are estimated to be 50 times more likely to acquire HCV than HIV-negative men. The study recruited men from the HCV cohort at Mortimer Market in London.


Read more:
AIDs Map News

 

Hepatitis C Infection Doubles Risk for Kidney Cancer

Physicians at Henry Ford Hospital have found that Hepatitis C infected patients had nearly double the risk of developing kidney cancer, after assessing age, gender, race, and underlying kidney disease. These results show that the hepatitis C virus causes disease that extends beyond the liver, and in fact most of our HCV-infected kidney cancer patients had only minimal liver damage. This establishes the need for a more careful surveillance of newly diagnosed kidney cancer patients for the presence of hepatitis C infection, one of the few cancers with a rising global incidence.
 

Read more: Health News Digest



New Drug Cures Hard-to-Treat Hepatitis C

Telaprevir is one of two highly anticipated drugs in the class known as protease inhibitors being studied in patients with chronic hepatitis C infection, a condition that affects about 3 million Americans and is the leading cause of liver transplants in the U.S. About 40% of previously untreated HCV patients are cured with the current treatment regimen, which includes 48 weeks of peginterferon and Ribavirin. A second round of treatment is often recommended for patients who fail to respond to initial treatment or who respond and then relapse. When the drug telaprevir was added to standard treatment with peginterferon Alfa and Ribavirin, which are also antiviral, about half of patients who had failed previous treatment with the two drugs cleared the virus.


Read more: WebMD

 

Liver Test For Kids Inaccurate

A new study shows that the routine screening test used to detect liver problems in children is being interpreted differently across the nation, allowing many cases to go undetected. The study at the University of California, San Diego, School of Medicine has been revealed that the common screening test for chronic liver disease that uses serum alanine aminotransferease (ALT) is using different values to detect risks for kids

across many of the nation's children's hospitals. The children were placed in four groups to a new limit of normal ALT: children with normal livers; with chronic hepatitis B virus; with hepatitis C virus; and children with non-alcoholic fatty liver disease. The study revealed only one-third to one-half of children with liver disease would be detected by the old standards and that the new values established by the study would improve detection to 70 to 80 percent.

 
Read more: Children's Health Channel

 

HCV Therapy Fails in Many Urban Patients

The standard treatment for hepatitis C, which is highly effective in clinical trials, may be unavailable, inappropriate, or ineffective in urban U.S. patients. In clinical trials, treatment with Pegylated Interferon and Ribavirin, yielded sustained viral response rates between 54% and 63%. But in an urban population, with many members of ethnic minorities, sustained viral response rates were between 14% and 37%. The study also confirms that members of ethnic minorities, who are usually under-represented in clinical trials, do not fare as well as expected with treatment in the real world. Physicians need to know not only the efficacy of combination therapy as demonstrated in phase III registration trials, but also its effectiveness: the outcome of treatment in patients like their own receiving ordinary clinical care.
 

Read more: MedPage Today




Tattoo Shops Regulations Tightened

 

The San Bernardino County Board of Supervisors unanimously voted to support legislation that would tighten up regulation of oversight of businesses that provide tattooing, body piercing and permanent cosmetic application services. The Safe Body Art Act would establish minimum statewide health and oversight standards for tattoo parlors and body art businesses. The absence of statewide regulations and standards puts public health at risk by increasing the threat of blood-borne diseases, particularly Hepatitis C and HIV. Researchers at the Centers for Disease Control and Prevention have linked clusters of antibiotic-resistant skin infections to unlicensed tattoo artists who didn't follow proper sterilization and needle disposal procedures.

Read more: http://www.sbsun.com/sports/ci_14687937#ixzz0iRwr2fZg




20 PERCENT OF AT-RISK NEWBORNS ARE NOT RECEIVING PREVENTATIVE

HEPATITIS B VACCINE AND TREATMENTS, STUDY REVEALS

March 12, 2010, 01:03 pm
 

Approximately 20 percent of infants born to mothers with hepatitis B are not receiving the proper preventative treatments, researchers at the U.S. Centers for Disease Control and Prevention (CDC) found in a recent study published in the April 2010 issue of Pediatrics. Infants who receive the hepatitis B vaccine and hepatitis B immunoglobulin (an injection of hepatitis B antibodies) are 85 to 95 percent protected from the disease. CDC researchers examined medical records of 4,762 mothers and 4,786 infants, with 18 women testing positive for hepatitis B upon admission to the hospital.

 

According to CDC epidemiologist and study author Bayo Wills, transmission of hepatitis B is almost entirely preventable through vaccination and proper medical procedures created to protect people from the disease. "We really need hospitals to have correct policies in place and to implement those policies so that every newborn is protected before they leave the hospital," said Willis. Recommendations provided by the CDC state that newborns should receive the hepatitis B vaccine at birth, followed by booster shots at one and six months old. Of the 190 hospitals examined in the study, only 67 percent had a policy in place to ensure hepatitis B vaccination. "The greatest predictor of which children would get the hepatitis vaccine was the hospital having a policy for universal vaccination of infants. Our study shows that gaps still persist in perinatal hepatitis prevention," added Willis.

 

Though 62 percent of the infants of hepatitis B-positive mothers received the proper hepatitis B vaccination and immunoglobulin, approximately 14 percent of the newborns did not receive the vaccination, while nearly 20 percent did not receive the injection of hepatitis B immunoglobulin before leaving the hospital. Approximately 52 percent of babies born to an additional 320 women with an unknown hepatitis B status received the hepatitis B vaccine within 12 hours of birth, while 20 percent of the infants left the hospital unvaccinated. Additional information about drugs and drug side effects [1] may be found on DrugWatch.com.


 


 

   Miss Apple Blossom Takes Liver Messages to School
 

Shannon Beam, Miss Apple Blossom Festival 2010, has joined Hepatitis Foundation International as a spokesperson, taking
important liver health messages to Virginia public schools. Shannon, who will be competing for the title of Miss Virginia this summer, will be integrating key ideas from HFI's unique
approach towards liver wellness and preventing unhealthy behaviors into her work of teaching students about the negative effects of alcohol and drug use on the liver.

 

 



CEO Receives Lifetime Achievement Award

                                                                                                                      On March 7 and 8, 2010, the Digestive Disease National
 Coalition (DDNC) held its 20th Annual National Public Policy
 Forum in Washington, DC.  Thelma King Thiel, Chair and CEO of
 Hepatitis Foundation International,  was awarded the Lifetime
 Achievement Award for her contributions to the DDNC as one of
 the co-founders of the coalition. Members of 125 organizations
 were in attendance to applaud Thelma for her efforts in
 influencing legislators with regard to health policy and funding.
 After forty years of hard work and dedication to the cause,
 Thelma continues on with her mission to promote awareness
 about liver disease prevention and to educate the public on
 how to take responsibility for their own health care.

 

Thelma has influenced people all over the world throughout the years with her charming and witty presentations that healthcare providers and “regular folks” alike can relate to.  The award recognizing her support for the digestive disease activist community was presented to Thelma by the DDNC's Chairperson Linda Aukett.




   New Drug Impacts Encephalopathy.

  Salix Pharmaceuticals Ltd. has reported that the FDA's Gastrointestinal Drugs Advisory
  Committee has approved XIFAFAN, a medication for the treatment of hepatic
  encephalopathy (HE). HE is a neurological disorder that is caused by chronic liver failure
  resulting in cognitive, psychiatric, and motor impairments. Patients with cirrhosis develop
  this condition which involves neuropsychiatric abnormalities caused by the liver's inability
  to remove toxic products from the blood, such as ammonia producing bacteria. Cirrhosis
  is typically caused by alcohol and drug abuse, chronic viral hepatitis, and autoimmune
  disease and is also a leading cause of death in the US. XIFAFAN is the first potential
  treatment option for patients with HE, giving new hope to over 200,000 Americans who
  suffer from this debilitating disease.

   
http://www.biospace.com/news_story.aspx?NewsEntityId=171516

 

   

    Paper "Chips" for Diagnosis of HIV and Hepatitis Could Provide Cheap Diagnosis
       of HIV and Hepatitis and other diseases

 

  A Harvard University chemistry professor has developed a prototype for a small "paper
  chip" that may serve as a cheap and accessible way for people to diagnose diseases
  from their own homes. The chip works by placing a drop of blood onto a small square
  piece of paper filled with water-repellent ink, which then funnels the blood into different
  channels creating a colored pattern shaped like a tree on the opposite side. By analyzing
  the ink's color and distribution, a person would be able to diagnose a number of diseases
  such as malaria, HIV, Hepatitis, and gastroenteritis as well as the level of infection. This
  cost efficient technology is expected to radically change health care in developing
  nations.
  

http://www.switched.com/2010/02/25/paper-chips-could-provide-cheap-diagnosis-of-hiv-and-hepatitis/

 



Travel Clinic Prepares Students for Spring Break Abroad:

West Virginia University's International Travel Clinic has taken up the initiative to educate students on the health risks associated with certain travel destinations that students may visit during their spring break vacations. As many students will be traveling abroad this spring, the travel clinic is available for student inquiry about immunizations via personal appointment and phone consultations. Healthcare employees at the clinic recommend that students be immunized for Hepatitis A, Hepatitis B, and tetanus before going abroad. The travel clinic uses recommendations set forth by the International Association of Medical Assistance to Travelers, an organization that combines the efforts of the Center for Disease Control, the World Health Organization, and state departments across the US. 
  

http://www.thedaonline.com/news/travel-clinic-prepares-students-for-spring-break-abroad-1.1171315

 

Hepatic Steatosis in Hepatitis C is a Storage Disease Due to HCV Interaction With Microsomal Triglyceride Transfer:

Liver steatosis, a condition that develops due to a degeneration of lipids within liver cells is common in patients with chronic Hepatitis C. New research shows that the relationship between the virus and steatosis is the result of both epigenetic and genetic factors. The study found that Hepatitis C can alter standard lipid metabolism within the liver because of an interaction between the virus and MTP. Based on these results, researchers concluded that steatosis associated with hepatitis C could be a storage disease induced by the effects of the virus and may cause more persistent infection in persons with HCV.
 

http://www.nafwa.org/nafwa-library/129-free-full-text-articles-and-books/3577-hepatic-steatosis-in-hepatitis-c-is-a-storage-disease-due-to-hcv-interaction-with-microsomal-triglyceride-transfer-protein-mtp



Reliable Biomarker Needed to Improve Diagnosis Methods of Liver Cancer

Dr. Anna S. Lok of the University of Michigan Medical Center has recently published the results of a study on biomarkers in the diagnosis of liver cancer. Liver cancer is the third most common cause of cancer-related deaths worldwide and its increasing prevalence in the US is largely attributed to cases of Hepatitis C. Currently, ultra-sonography is the preferred surveillance method for liver cancer, but many cases are not detected until later stages of progression. Lok's study showed that serum indicators varied by patient demographics, a factor that may be integral in improving this method of diagnosis for liver cancer, preventing late-stage diagnosis and saving lives.

 
http://www.eurekalert.org/pub_releases/2010-02/aga-rbn022510.php


 



 

Thelma King Thiel Receives

Above and Beyond Citizen Award

HFI’s CEO Thelma King Thiel received the Above and Beyond Citizen Honors presented by the Congressional Medal of Honor Foundation as an unsung hero for her extraordinary courage and selflessness in promoting liver wellness and healthy lifestyles. Affectionately known as ”The Liver Lady”, Thelma has dedicated her life to educating people about the importance of liver health following the loss of her four-year-old son, Dean, to a rare liver disease four decades ago. Her inspirational message empowers individuals with knowledge and challenges them to take responsibility for their own health and wellness.  She is an inspiration to all who know her.


U.S. Expert Promotes Hepatitis Prevention at WHO Meeting in

Italy

   Hepatitis Foundation International’s (HFI) CEO, Thelma King Thiel, creator of the unique ”liver” cartoon and humorous messages about the liver, was invited to  share her techniques with representatives from the World Health Organization and 12 European countries at a meeting held in Lucca, Italy March 13-14, 2008. Calling the liver one’s personal power plant, she described how drugs, alcohol and hepatitis viruses attack and kill liver cells, the employees in this miraculous powerplant. She encouraged the attendees to engage caregivers, educators and patients in promoting liver wellness and healthy lifestyle behaviors to help bring viral hepatitis under control.

   Members of the Viral Hepatitis Prevention Board, affiliate of the World Health Organization (WHO), and the European Liver Patient Association (ELPA) welcomed having new and non-threatening techniques to enhance their efforts to prevent viral hepatitis and other blood borne pathogens.  Ms Thiel said, " Dollars devoted to prevention will circumvent the tragedy of this disease for individuals around the world, many of whom have no resources for treatment, if infected". 

   Ms Thiel was recommended by John W. Ward, M.D. Director, Division of Viral Hepatitis, Centers for Disease Control and Prevention to represent the United States and share her approach to prevention with the attendees.  Dr. Ward, who also attended the meeting, commented, “Your participation added a lot to the meeting particularly your passion for viral hepatitis prevention which the audience responded enthusiastically to at the end of your presentation.”

  The purpose of the meeting was to identify the role and impact of various partner agencies, organizations and patient groups on bringing hepatitis under control. Patient access to care and support for treatments for viral hepatitis were high priorities for many of the European organizations. The focus of Ms. Thiel’s presentation was to share new and easily replicated messages promoting primary and secondary prevention.

   Representatives from WHO/EURO, Belgium, Bulgaria, Croatia, Egypt, France, Germany, Italy, Poland, The Netherlands, and the UK received a copy of HFI’s Foundation for Decision Making Teacher’s Guide and a DVD called The Invisible Threat. Applauded for her exceptional educational approach, Ms. Thiel commented “I was encouraged by the positive response by several attendees as an educational “eye opener.”

   The Hepatitis Foundation International, a non profit organization located in Silver Spring, MD, is recognized internationally for its unique liver wellness approach, its series of 14 DVDs and educational materials promoting primary and secondary prevention of viral hepatitis and other blood borne pathogens.  HFI’s Foundation for Decision Making™ Training Program has been embraced by numerous government agencies including the Center for Substance Abuse Prevention and Center for Substance Abuse Treatment, numerous health departments and community organizations reaching thousands of educators, healthcare providers, substance abuse and mental health counselors, and social workers.

 

HFI Chief Represented USA at European Liver Meeting

     The Viral Hepatitis Prevention Board, WHO Collaborating Centre for Prevention and Control of Viral Hepatitis, and the European Liver Patient Association will hold a meeting on “Preventing and control of viral hepatitis; the role and impact of liver patient groups in and outside Europe” in Lucca, Italy, March 13, 14 2008. The purpose of the meeting is to open a dialogue to identify the role and impact of various partner agencies, organizations and patient groups. Thelma King Thiel, Chair and CEO of the Hepatitis Foundation International (HFI) will be representing the United States reporting on prevention initiatives and collaborative efforts with patient groups, local and federal government agencies and the Center for Disease Control and Prevention.  “I look forward to sharing our unique primary and secondary prevention program and materials called Foundation for Decision Making with several European countries,” says Thiel.  “Our mutual goal is to bring viral hepatitis under control and to improve outcomes of patients in treatment.” 
      Representatives attended from WHO/EURO, Belgium, Bulgaria, Croatia, Egypt, France, Germany, Italy, Poland, The Netherlands, the UK and the United States.
  Attendees will preview HFI’s recently produced EMMY Award winning DVD for young adults called Give Your Liver a Break. This is one of 14 educational DVDs HFI has produced targeting young children, adolescents, college students, patients, healthcare providers and another for those who participate in high risk behaviors. Each DVD uses animation depicting how cirrhosis occurs and identifies modes of transmission of hepatitis viruses in several languages for various ethnic groups.  All DVDs are available for viewing at www.hepatitisfoundation.org

 

Give Your Liver a Break DVD wins Emmy

     The National Academy of Arts and Sciences presented the Emmy Award for outstanding achievement in television programming for children to Hepatitis Foundation International's newest production, "Give Your Liver a Break".  Bill Shomo accepted the award at the Emmy Awards Ceremony held in Orlando, Florida.  Kudos to Bill, President of Chaumont Communications, who co-produced the DVD with HFI.

     "Through Bill's exceptional ability to tailor messages promoting liver wellness to various audience's in the series of fourteen DVDs he has created for HFI, millions of viewers, young and old, have received messages to help them live healthier lives," said Thelma King Thiel, HFI's CEO.

     "Give Your Liver a Break" and other HFI DVDs are available for viewing on our website, to preview, Click Here.

 

Strive 2011

 

   

 

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